Understanding the mode-of-action of Cassia auriculata via in silico and in vivo studies towards validating it as a long term therapy for type II diabetes.

Mohd Fauzi, Fazlin; John, Cini Mathew; Karunanidhi, Arunkumar; Mussa, Hamse Y; Ramasamy, Rajesh; Adam, Aishah; Bender, Andreas

Mohd Fauzi, Fazlin; John, Cini Mathew; Karunanidhi, Arunkumar; Mussa, Hamse Y; Ramasamy, Rajesh; Adam, Aishah; Bender, Andreas.

Afiliação

Mohd Fauzi F; Department of Pharmacology and Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia; Center for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom. Electroni
John CM; Department of Pharmacology and Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia; Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, AB, Canada T2N 4N1.
Karunanidhi A; Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia.
Mussa HY; Center for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom.
Ramasamy R; Immunology Unit, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia.
Adam A; Department of Pharmacology and Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.
Bender A; Center for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom.

J Ethnopharmacol ; 197: 61-72, 2017 Feb 02.

Article em En | MEDLINE | ID: mdl-27452659

Assuntos

Cassia/química; Diabetes Mellitus Tipo 2/tratamento farmacológico; Extratos Vegetais/farmacologia; Animais; Diabetes Mellitus Experimental/tratamento farmacológico; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Tipo 2/metabolismo; Transportador de Glucose Tipo 2/metabolismo; Transportador de Glucose Tipo 4/metabolismo; Insulina/metabolismo; Proteínas Substratos do Receptor de Insulina/metabolismo; Fígado/efeitos dos fármacos; Fígado/metabolismo; PPAR gama/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ratos; Ratos Sprague-Dawley; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Cassia auriculata; Chrysin (PubChem CID: 5281607); Ellagic acid (PubChem CID: 5281855); Epigallocatechin gallate (PubChem CID: 65064); Immunometabolic pathway; In silico target prediction; Kaempferol 7-O-rhamnoside-4'-O-glucoside (PubChem CID: 5280863); Luteolin (PubChem CID: 5280445); Mode of action; PI3K signalling pathway; PPAR-Î³; Procyanidin B2 (PubChem CID: 122738); Quercetin-3-O-ß-D-glucopyranoside (PubChem CID: 15959354); Taxifolin (PubChem CID: 439533); ± Catechin (PubChem CID: 9064), 1,2-benzenedicarboxylic acid bis(2-methylpropyl)ester (PubChem CID: 3085853/92160557)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Cassia / Diabetes Mellitus Tipo 2 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2017 Tipo de documento: Article

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