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A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model.
Wang, Fang; Travins, Jeremy; Lin, Zhizhong; Si, Yaguang; Chen, Yue; Powe, Josh; Murray, Stuart; Zhu, Dongwei; Artin, Erin; Gross, Stefan; Santiago, Stephanie; Steadman, Mya; Kernytsky, Andrew; Straley, Kimberly; Lu, Chenming; Pop, Ana; Struys, Eduard A; Jansen, Erwin E W; Salomons, Gajja S; David, Muriel D; Quivoron, Cyril; Penard-Lacronique, Virginie; Regan, Karen S; Liu, Wei; Dang, Lenny; Yang, Hua; Silverman, Lee; Agresta, Samuel; Dorsch, Marion; Biller, Scott; Yen, Katharine; Cang, Yong; Su, Shin-San Michael; Jin, Shengfang.
Afiliação
  • Wang F; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Travins J; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Lin Z; Oncology Business Unit, WuXi AppTec, Shanghai, China.
  • Si Y; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Chen Y; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Powe J; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Murray S; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Zhu D; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Artin E; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Gross S; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Santiago S; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Steadman M; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Kernytsky A; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Straley K; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Lu C; Oncology Business Unit, WuXi AppTec, Shanghai, China.
  • Pop A; Metabolic Unit, Department of Clinical Chemistry, VU University Medical Center/ Neuroscience Campus, Amsterdam, The Netherlands.
  • Struys EA; Metabolic Unit, Department of Clinical Chemistry, VU University Medical Center/ Neuroscience Campus, Amsterdam, The Netherlands.
  • Jansen EE; Metabolic Unit, Department of Clinical Chemistry, VU University Medical Center/ Neuroscience Campus, Amsterdam, The Netherlands.
  • Salomons GS; Metabolic Unit, Department of Clinical Chemistry, VU University Medical Center/ Neuroscience Campus, Amsterdam, The Netherlands.
  • David MD; Institut National de la Santé et de la Recherche Médicale, INSERM U1170, Villejuif, France.
  • Quivoron C; Institut Gustave Roussy, Villejuif, France.
  • Penard-Lacronique V; Institut National de la Santé et de la Recherche Médicale, INSERM U1170, Villejuif, France.
  • Regan KS; Institut Gustave Roussy, Villejuif, France.
  • Liu W; Institut National de la Santé et de la Recherche Médicale, INSERM U1170, Villejuif, France.
  • Dang L; Institut Gustave Roussy, Villejuif, France.
  • Yang H; Regan Pathology/Toxicology Services, Ashland, OH, USA.
  • Silverman L; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Agresta S; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Dorsch M; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Biller S; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Yen K; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Cang Y; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Su SM; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
  • Jin S; Agios Pharmaceuticals Inc., 88 Sidney Street, Cambridge, MA, 02139-4169, USA.
J Inherit Metab Dis ; 39(6): 807-820, 2016 11.
Article em En | MEDLINE | ID: mdl-27469509
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encefalopatias Metabólicas Congênitas / Bibliotecas de Moléculas Pequenas / Isocitrato Desidrogenase / Mutação / Cardiomiopatias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Inherit Metab Dis Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encefalopatias Metabólicas Congênitas / Bibliotecas de Moléculas Pequenas / Isocitrato Desidrogenase / Mutação / Cardiomiopatias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Inherit Metab Dis Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos