Population Polymorphism of IFNL3 and IFNL4 Genes of Type 3 Interferon Associated with Spontaneous Clearance of Hepatitis C Virus in Representatives of Caucasian and Mongoloid Races.

Malov, I V; Malov, S I; Savilov, E D; Gantulga, D; Stepanenko, L A; Ogarkov, O B; Nyamkhuu, D; Aitov, K A; Nyamdawa, P; Kolesnikov, S I

Malov, I V; Malov, S I; Savilov, E D; Gantulga, D; Stepanenko, L A; Ogarkov, O B; Nyamkhuu, D; Aitov, K A; Nyamdawa, P; Kolesnikov, S I.

Afiliação

Malov IV; Irkutsk State Medical University, Irkutsk, Russia.
Malov SI; Irkutsk State Medical University, Irkutsk, Russia. sikolesnikov2012@gmail.com.
Savilov ED; Research Center of Problems of Family Health and Human Reproduction, Irkutsk, Russia.
Gantulga D; Irkutsk State Medical Academy of Post-Graduate Education, Irkutsk, Russia.
Stepanenko LA; National Center of Investigation of Infectious Diseases, Ulan-Bator, Mongolia.
Ogarkov OB; Irkutsk State Medical University, Irkutsk, Russia.
Nyamkhuu D; Research Center of Problems of Family Health and Human Reproduction, Irkutsk, Russia.
Aitov KA; Irkutsk State Medical Academy of Post-Graduate Education, Irkutsk, Russia.
Nyamdawa P; National Center of Investigation of Infectious Diseases, Ulan-Bator, Mongolia.
Kolesnikov SI; Irkutsk State Medical University, Irkutsk, Russia.

Bull Exp Biol Med ; 161(3): 404-7, 2016 Jul.

Article em En | MEDLINE | ID: mdl-27492404

ABSTRACT

ABSTRACT

The frequency of single nucleotide polymorphisms of IFNL3 gene (rsl12979860 and rs8099917) and dinucleotide polymorphism of IFNL4 gene (ss469415590) were estimated in healthy inhabitants of Mongolia and Irkutsk regions taking into account their races. Population and genetic studies were performed in 1520 conventionally healthy volunteers (blood donors), representatives of Caucasian and Mongoloid races. Significant race-related differences in the incidence of IFNL3 and IFNL4 gene polymorphisms associated with spontaneous clearance of hepatitis C virus were found in healthy volunteers.

Assuntos

Hepacivirus/patogenicidade; Interleucinas/genética; Povo Asiático; Predisposição Genética para Doença/genética; Genótipo; Voluntários Saudáveis; Humanos; Interferons; Polimorfismo de Nucleotídeo Único/genética; População Branca

Palavras-chave

Caucasians; IFNL3; IFNL4; Mongoloids; genetic polymorphism

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucinas / Hepacivirus Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Federação Russa

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