MicroRNA-21 Mediates Angiotensin II-Induced Liver Fibrosis by Activating NLRP3 Inflammasome/IL-1ß Axis via Targeting Smad7 and Spry1.

Ning, Zuo-Wei; Luo, Xiao-Ying; Wang, Guo-Zhen; Li, Yang; Pan, Miao-Xia; Yang, Ren-Qiang; Ling, Xu-Guang; Huang, Shan; Ma, Xiao-Xin; Jin, Si-Yi; Wang, Dan; Li, Xu

Ning, Zuo-Wei; Luo, Xiao-Ying; Wang, Guo-Zhen; Li, Yang; Pan, Miao-Xia; Yang, Ren-Qiang; Ling, Xu-Guang; Huang, Shan; Ma, Xiao-Xin; Jin, Si-Yi; Wang, Dan; Li, Xu.

Afiliação

Ning ZW; 1 Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China .
Luo XY; 1 Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China .
Wang GZ; 1 Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China .
Li Y; 1 Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China .
Pan MX; 2 Department of Respiratory Diseases, Southern Medical University , Guangzhou, China .
Yang RQ; 3 Department of Emergency Medicine, Nanfang Hospital, Southern Medical University , Guangzhou, China .
Ling XG; 3 Department of Emergency Medicine, Nanfang Hospital, Southern Medical University , Guangzhou, China .
Huang S; 1 Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China .
Ma XX; 1 Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China .
Jin SY; 1 Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China .
Wang D; 1 Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China .
Li X; 1 Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University , Guangzhou, China .

Antioxid Redox Signal ; 27(1): 1-20, 2017 07 01.

Article em En | MEDLINE | ID: mdl-27502441

Assuntos

Angiotensina II/farmacologia; Inflamassomos/metabolismo; Cirrose Hepática/genética; MicroRNAs/genética; Animais; Células Cultivadas; Modelos Animais de Doenças; Regulação da Expressão Gênica/efeitos dos fármacos; Células Estreladas do Fígado/efeitos dos fármacos; Células Estreladas do Fígado/metabolismo; Humanos; Interleucina-1beta/metabolismo; Cirrose Hepática/metabolismo; Proteínas de Membrana; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Fosfoproteínas; Ratos; Proteína Smad7/metabolismo

Palavras-chave

NLRP3 inflammasome; angiotensin II; angiotensin-(1-7); liver fibrosis; microRNA 21; reactive oxygen species

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Angiotensina II / MicroRNAs / Inflamassomos / Cirrose Hepática Limite: Animals / Humans Idioma: En Revista: Antioxid Redox Signal Assunto da revista: METABOLISMO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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