Your browser doesn't support javascript.
loading
Association between antiphospholipid antibodies and arterial thrombosis in patients with rheumatoid arthritis.
Kim, K-J; Baek, I-W; Park, K-S; Kim, W-U; Cho, C-S.
Afiliação
  • Kim KJ; Division of Rheumatology, St Vincent Hospital, Suwon, Republic of Korea.
  • Baek IW; Division of Rheumatology, Yeouido St Mary's Hospital, Seoul, Republic of Korea.
  • Park KS; Division of Rheumatology, St Vincent Hospital, Suwon, Republic of Korea.
  • Kim WU; Division of Rheumatology, Seoul St Mary's Hospital, Seoul, Republic of Korea.
  • Cho CS; Division of Rheumatology, Yeouido St Mary's Hospital, Seoul, Republic of Korea chocs@catholic.ac.kr.
Lupus ; 26(1): 88-94, 2017 Jan.
Article em En | MEDLINE | ID: mdl-27510601
ABSTRACT

OBJECTIVES:

Antiphospholipid antibodies (aPL) are present in a proportion of patients with rheumatoid arthritis but their clinical significance remains unclear. We investigated the association between aPL and thrombotic events in rheumatoid arthritis patients.

METHODS:

In this cross-sectional study, aPL profiles were evaluated in 376 rheumatoid arthritis patients in accordance with the standard guidelines. Clinical and radiographic data were retrospectively collected.

RESULTS:

aPL were identified in 39 patients (10.4%). Lupus anticoagulant was the most common subtype (n = 25, 6.6%); anti-cardiolipin antibodies and anti-ß2 glycoprotein I antibodies were detected in six and 12 patients (1.6% and 3.2%), respectively. Compared to the aPL-negative group, aPL-positive patients included more male patients (41.0% vs. 15.4%, P < 0.001) and more smokers (41.0% vs. 16.0%, P = 0.001). There was no difference between the two groups in age, disease duration and body mass index, or the frequency of diabetes, hypertension or dyslipidaemia. Of note, arterial thromboses were more common in the aPL-positive than the aPL-negative group (12.8% vs. 2.1%, P = 0.004), whereas the frequency of venous thrombosis did not differ between the two groups (0.0% vs. 0.9%, P = 1.000). On multivariate regression analysis, aPL, age, hypertension, dyslipidaemia and baseline C-reactive protein level were independently associated with arterial thrombotic events (all P values < 0.05).

CONCLUSION:

aPL was found in a subset of rheumatoid arthritis patients, who were more often smokers, and aPL was independently associated with development of arterial thrombosis. This result suggests that aPL may contribute to an increased risk of arterial thrombosis in rheumatoid arthritis patients.
Assuntos
Palavras-chave
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Trombose / Anticorpos Antifosfolipídeos Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Lupus Assunto da revista: REUMATOLOGIA Ano de publicação: 2017 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Trombose / Anticorpos Antifosfolipídeos Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Lupus Assunto da revista: REUMATOLOGIA Ano de publicação: 2017 Tipo de documento: Article