Inverse stereoselectivity in the binding of acenocoumarol to human serum albumin and to alpha 1-acid glycoprotein.
Biochem Pharmacol
; 38(14): 2259-62, 1989 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-2751692
ABSTRACT
Stereoselective binding of rac-acenocoumarol to human serum albumin (HSA) and alpha 1-acid glycoprotein (alpha 1-AGP) was investigated by affinity chromatography and by combined ultrafiltration (UF) and circular dichroism (CD) methods. For HSA, the ratio of the enantiomeric constants was KR/KS = 2, while for alpha 1-AGP, KS/KR = 3.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Orosomucoide
/
Albumina Sérica
/
Acenocumarol
Limite:
Humans
Idioma:
En
Revista:
Biochem Pharmacol
Ano de publicação:
1989
Tipo de documento:
Article