Effects of isoxsuprine hydrochloride on electrocardiographic and trace element status in sheeps.
J Pak Med Assoc
; 66(8): 938-42, 2016 Aug.
Article
em En
| MEDLINE
| ID: mdl-27524523
ABSTRACT
OBJECTIVE:
To study the effect of isoxsuprine hydrochloride on the ischaemic electrocardiographic change and trace element status in sheep.METHODS:
This study was conducted from March 16 to 23, 2012, at Istanbul University, Turkey, and comprised sheep aged 6 months. The animals were divided into two equal groups. The control group was fed a standard diet and had free access to water. In the experimental group, isoxsuprine hydrochloride was injected at a dose of 0.6 mg/kg through the intramuscular route. Electrocardiographic changes, including creatine kinase and cardiac troponin-I, and serum levels of selenium, copper, calcium, magnesium, iron and zinc were investigated in healthy sheep. SPSS 15 was used for statistical analysis.RESULTS:
The 14 sheep were divided into two groups of 7(50%) each. The overall mean weight of the study population was 35±10kg. Selenium, calcium, iron and zinc concentrations did not show any difference in serum samples (p>0.05). However, copper and magnesium concentrations decreased in serum after the administration of the drug (p<0.05). In the experimental group, ST segment depression and abnormal T-wave was found in 6(86%) animals within 60min.CONCLUSIONS:
Isoxsuprine hydrochloride increased cardiotoxicity risk in sheep.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Agonistas Adrenérgicos beta
/
Troponina I
/
Eletrocardiografia
/
Creatina Quinase Forma MB
/
Coração
/
Isoxsuprina
Limite:
Animals
Idioma:
En
Revista:
J Pak Med Assoc
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Turquia