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Syntheses of Denudatine Diterpenoid Alkaloids: Cochlearenine, N-Ethyl-1α-hydroxy-17-veratroyldictyzine, and Paniculamine.
Kou, Kevin G M; Li, Beryl X; Lee, Jack C; Gallego, Gary M; Lebold, Terry P; DiPasquale, Antonio G; Sarpong, Richmond.
Afiliação
  • Kou KG; Department of Chemistry, University of California , Berkeley, California 94720, United States.
  • Li BX; Department of Chemistry, University of California , Berkeley, California 94720, United States.
  • Lee JC; Department of Chemistry, University of California , Berkeley, California 94720, United States.
  • Gallego GM; Department of Chemistry, University of California , Berkeley, California 94720, United States.
  • Lebold TP; Department of Chemistry, University of California , Berkeley, California 94720, United States.
  • DiPasquale AG; Department of Chemistry, University of California , Berkeley, California 94720, United States.
  • Sarpong R; Department of Chemistry, University of California , Berkeley, California 94720, United States.
J Am Chem Soc ; 138(34): 10830-3, 2016 08 31.
Article em En | MEDLINE | ID: mdl-27525345
ABSTRACT
The denudatine-type diterpenoid alkaloids cochlearenine, N-ethyl-1α-hydroxy-17-veratroyldictyzine, and paniculamine have been synthesized for the first time (25, 26, and 26 steps from 16, respectively). These syntheses take advantage of a common intermediate (8) that we have previously employed in preparing aconitine-type natural products. The syntheses reported herein complete the realization of a unified strategy for the preparation of C20, C19, and C18 diterpenoid alkaloids.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diterpenos / Alcaloides Idioma: En Revista: J Am Chem Soc Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diterpenos / Alcaloides Idioma: En Revista: J Am Chem Soc Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos