The Axon Protective Effects of Syringic Acid on Ischemia/Reperfusion Injury in a Rat Sciatic Nerve Model.
Turk Neurosurg
; 27(1): 124-132, 2017.
Article
em En
| MEDLINE
| ID: mdl-27593755
ABSTRACT
AIM:
In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury. MATERIAL ANDMETHODS:
The rats were randomly divided into four groups Control group (no medication or surgical procedure), Sham group, Syringic acid group, and Methyprednisolone (MP) Group. Ischemia was achieved by abdominal aorta clamping and all animals were sacrificed 24 hours after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry.RESULTS:
Ischemic fiber degeneration scores were found significantly lower in syringic acid and MP groups than sham group. Additionally, apoptosis-related cysteine peptidase caspase-3 immunostaining scores were lower in syringic acid and MP groups. Biochemically, superoxide dismutase and nuclear respiratory factor 1 values were significantly higher in syringic acid group compared to those of control and sham groups while malondialdehyde levels were significantly lower in the syringic acid group.CONCLUSION:
Syringic acid reduces oxidative stress and axonal degeneration in rat sciatic nerve after ischemia/reperfusion injury. Therefore, syringic acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nervo Isquiático
/
Axônios
/
Traumatismo por Reperfusão
/
Traumatismos dos Nervos Periféricos
/
Ácido Gálico
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Turk Neurosurg
Assunto da revista:
NEUROCIRURGIA
Ano de publicação:
2017
Tipo de documento:
Article