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Amyloid structure exhibits polymorphism on multiple length scales in human brain tissue.
Liu, Jiliang; Costantino, Isabel; Venugopalan, Nagarajan; Fischetti, Robert F; Hyman, Bradley T; Frosch, Matthew P; Gomez-Isla, Teresa; Makowski, Lee.
Afiliação
  • Liu J; Department of Bioengineering, Northeastern University, Boston, MA, USA.
  • Costantino I; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Boston, MA, USA.
  • Venugopalan N; GM/CA@APS, Argonne National Laboratory, Illnois 60439, USA.
  • Fischetti RF; GM/CA@APS, Argonne National Laboratory, Illnois 60439, USA.
  • Hyman BT; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Boston, MA, USA.
  • Frosch MP; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Boston, MA, USA.
  • Gomez-Isla T; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Boston, MA, USA.
  • Makowski L; Department of Bioengineering, Northeastern University, Boston, MA, USA.
Sci Rep ; 6: 33079, 2016 09 15.
Article em En | MEDLINE | ID: mdl-27629394
ABSTRACT
Aggregation of Aß amyloid fibrils into plaques in the brain is a universal hallmark of Alzheimer's Disease (AD), but whether plaques in different individuals are equivalent is unknown. One possibility is that amyloid fibrils exhibit different structures and different structures may contribute differentially to disease, either within an individual brain or between individuals. However, the occurrence and distribution of structural polymorphisms of amyloid in human brain is poorly documented. Here we use X-ray microdiffraction of histological sections of human tissue to map the abundance, orientation and structural heterogeneities of amyloid. Our observations indicate that (i) tissue derived from subjects with different clinical histories may contain different ensembles of fibrillar structures; (ii) plaques harboring distinct amyloid structures can coexist within a single tissue section and (iii) within individual plaques there is a gradient of fibrillar structure from core to margins. These observations have immediate implications for existing theories on the inception and progression of AD.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Placa Amiloide Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Placa Amiloide Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos