Independent Component Analysis of Resting-State Functional Magnetic Resonance Imaging in Pedophiles.
J Sex Med
; 13(10): 1546-54, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27641922
ABSTRACT
INTRODUCTION:
Neuroimaging and other studies have changed the common view that pedophilia is a result of childhood sexual abuse and instead is a neurologic phenomenon with prenatal origins. Previous research has identified differences in the structural connectivity of the brain in pedophilia.AIM:
To identify analogous differences in functional connectivity.METHODS:
Functional magnetic resonance images were recorded from three groups of participants while they were at rest pedophilic men with a history of sexual offenses against children (n = 37) and two control groups non-pedophilic men who committed non-sexual offenses (n = 28) and non-pedophilic men with no criminal history (n = 39). MAIN OUTCOMEMEASURE:
Functional magnetic resonance imaging data were subjected to independent component analysis to identify known functional networks of the brain, and groups were compared to identify differences in connectivity with those networks (or "components").RESULTS:
The pedophilic group demonstrated wide-ranging increases in functional connectivity with the default mode network compared with controls and regional differences (increases and decreases) with the frontoparietal network. Of these brain regions (total = 23), 20 have been identified by meta-analytic studies to respond to sexually relevant stimuli. Conversely, of the brain areas known to be those that respond to sexual stimuli, nearly all emerged in the present data as significantly different in pedophiles.CONCLUSION:
This study confirms the presence of significant differences in the functional connectivity of the brain in pedophilia consistent with previously reported differences in structural connectivity. The connectivity differences detected here and elsewhere are opposite in direction from those associated with anti-sociality, arguing against anti-sociality and for pedophilia as the source of the neuroanatomic differences detected.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pedofilia
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Delitos Sexuais
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Encéfalo
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Mapeamento Encefálico
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Child
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Humans
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Male
Idioma:
En
Revista:
J Sex Med
Assunto da revista:
GINECOLOGIA
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MEDICINA REPRODUTIVA
/
UROLOGIA
Ano de publicação:
2016
Tipo de documento:
Article