Mechanism and Anticancer Activity of the Metabolites of an Endophytic Fungi from Eucommia ulmoides Oliv.
Anticancer Agents Med Chem
; 17(7): 982-989, 2017.
Article
em En
| MEDLINE
| ID: mdl-27671307
ABSTRACT
Backgroud Pinoresinol (Pin) and pinoresinol monoglucoside (PMG) are plant-derived lignan molecules with multiple functions. We showed previously that an endophytic fungus from Eucommia ulmoides Oliv., Phomopsis sp. XP-8 is able to produce Pin and PMG. OBJECTIVE:
This study was carried out to test the anti-tumor capability of the culture of XP-8 and identify the major effective compounds.METHOD:
The fungal culture was added in the culture of HepG2 and K562 cells, and the viabilities of these cells were detected and the possible mechanism was analyzed.RESULT:
The fungal culture showed significant capaiblity in decreasing the viability of tumor cells and induce apoptosis via up-regulation of the expression of apoptosis-related genes. It also significantly inhibited the adhesion and migration of HepG2 cells by blocking MMP-9 expression. Pin and PMG were isolated from the growth culture and shown to be the major effective components for inhibition.CONCLUSION:
The study indicated the potential application of XP-8 in the production of anti-tumour products by the bioconversion of glucose.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lignanas
/
Eucommiaceae
/
Endófitos
/
Fungos
/
Furanos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Anticancer Agents Med Chem
Assunto da revista:
ANTINEOPLASICOS
/
QUIMICA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China