Lower cerebral blood flow is associated with impairment in multiple cognitive domains in Alzheimer's disease.
Alzheimers Dement
; 13(5): 531-540, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-27693109
ABSTRACT
INTRODUCTION:
We examined the association between decreased cerebral blood flow (CBF) and cognitive impairment in Alzheimer's disease (AD), mild cognitive impairment (MCI), and subjective cognitive decline (SCD).METHODS:
We included 161 AD, 95 MCI, and 143 SCD patients from the Amsterdam Dementia Cohort. We used 3-T pseudo-continuous arterial spin labeling to estimate whole-brain and regional partial volume-corrected CBF. Neuropsychological tests covered global cognition and five cognitive domains. Associations were investigated using linear regression analyses.RESULTS:
In the whole sample, reduced overall and regional CBF was associated with impairment in all cognitive domains. We found significant interactions between diagnosis and CBF for language and between diagnosis and parietal CBF for global cognition and executive functioning. Stratification showed that decreased CBF was associated with worse performance in AD patients but not in MCI or SCD.DISCUSSION:
Our results suggest that CBF may have potential as a functional marker of disease severity.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Circulação Cerebrovascular
/
Cognição
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Transtornos Cognitivos
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Doença de Alzheimer
Tipo de estudo:
Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Alzheimers Dement
Ano de publicação:
2017
Tipo de documento:
Article