RNA Editing Dynamically Rewrites the Cancer Code.
Trends Cancer
; 1(4): 211-212, 2015 12.
Article
em En
| MEDLINE
| ID: mdl-27695712
ABSTRACT
Global analyses of cancer transcriptomes demonstrate that ADAR (adenosine deaminase, RNA-specific)-mediated RNA editing dynamically contributes to genetic alterations in cancer, and directly correlates with progression and prognosis. RNA editing is abundant and frequently elevated in cancer, and affects functionally and clinically relevant sites in both coding and non-coding regions of the transcriptome. Therefore, ADAR and differentially edited transcripts may be promising biomarkers or targets for therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Ligação a RNA
/
Edição de RNA
Limite:
Humans
Idioma:
En
Revista:
Trends Cancer
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos