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Chlorotheolides A and B, Spiroketals Generated via Diels-Alder Reactions in the Endophytic Fungus Pestalotiopsis theae.
Liu, Ling; Han, Yu; Xiao, Junhai; Li, Li; Guo, Liangdong; Jiang, Xuejun; Kong, Lingyi; Che, Yongsheng.
Afiliação
  • Liu L; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101, People's Republic of China.
  • Han Y; State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology , Beijing 100850, People's Republic of China.
  • Xiao J; State Key Laboratory of Natural Medicines, China Pharmaceutical University , Nanjing 210009, People's Republic of China.
  • Li L; State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology , Beijing 100850, People's Republic of China.
  • Guo L; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050, People's Republic of China.
  • Jiang X; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101, People's Republic of China.
  • Kong L; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101, People's Republic of China.
  • Che Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University , Nanjing 210009, People's Republic of China.
J Nat Prod ; 79(10): 2616-2623, 2016 10 28.
Article em En | MEDLINE | ID: mdl-27731995
ABSTRACT
Chlorotheolides A (1) and B (2), two new spiroketals possessing the unique [4,7]methanochromene and dispiro-trione skeletons, respectively, and their putative biosynthetic precursors, 1-undecen-2,3-dicarboxylic acid (3) and maldoxin (4), were isolated from the solid substrate fermentation of the plant endophytic fungus Pestalotiopsis theae (N635). Their structures were elucidated based on NMR spectroscopic data and electronic circular dichroism calculations. Biogenetically, compounds 1 and 2 could be generated from the co-isolated 3 and 4 via Diels-Alder reactions. Chlorotheolide (2) showed an antiproliferative effect against the human tumor cell line HeLa and induced an autophagic process in the cells.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ascomicetos / Compostos de Espiro Limite: Humans País/Região como assunto: Asia Idioma: En Revista: J Nat Prod Ano de publicação: 2016 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ascomicetos / Compostos de Espiro Limite: Humans País/Região como assunto: Asia Idioma: En Revista: J Nat Prod Ano de publicação: 2016 Tipo de documento: Article