Estimation of the dietary requirement for vitamin D in white children aged 4-8 y: a randomized, controlled, dose-response trial.
Am J Clin Nutr
; 104(5): 1310-1317, 2016 11.
Article
em En
| MEDLINE
| ID: mdl-27733403
ABSTRACT
BACKGROUND:
Children in northern latitudes are at high risk of vitamin D deficiency during winter because of negligible dermal vitamin D3 production. However, to our knowledge, the dietary requirement for maintaining the nutritional adequacy of vitamin D in young children has not been investigated.OBJECTIVE:
We aimed to establish the distribution of vitamin D intakes required to maintain winter serum 25-hydroxyvitamin D [25(OH)D] concentrations above the proposed cutoffs (25, 30, 40, and 50 nmol/L) in white Danish children aged 4-8 y living at 55°N.DESIGN:
In a double-blind, randomized, controlled trial 119 children (mean age 6.7 y) were assigned to 0 (placebo), 10, or 20 µg vitamin D3/d supplementation for 20 wk. We measured anthropometry, dietary vitamin D, and serum 25(OH)D with liquid chromatography-tandem mass spectrometry at baseline and endpoint.RESULTS:
The mean ± SD baseline serum 25(OH)D was 56.7 ± 12.3 nmol/L (range 28.7-101.4 nmol/L). Serum 25(OH)D increased by a mean ± SE of 4.9 ± 1.3 and 17.7 ± 1.8 nmol/L in the groups receiving 10 and 20 µg vitamin D3/d, respectively, and decreased by 24.1 ± 1.2 nmol/L in the placebo group (P < 0.001). A nonlinear model of serum 25(OH)D as a function of total vitamin D intake (diet and supplements) was fit to the data. The estimated vitamin D intakes required to maintain winter serum 25(OH)D >30 (avoiding deficiency) and >50 nmol/L (ensuring adequacy) in 97.5% of participants were 8.3 and 19.5 µg/d, respectively, and 4.4 µg/d was required to maintain serum 25(OH)D >40 nmol/L in 50% of participants.CONCLUSIONS:
Vitamin D intakes between 8 and 20 µg/d are required by white 4- to 8-y-olds during winter in northern latitudes to maintain serum 25(OH)D >30-50 nmol/L depending on chosen serum 25(OH)D threshold. This trial was registered at clinicaltrials.gov as NCT02145195.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Necessidades Nutricionais
Tipo de estudo:
Clinical_trials
Limite:
Child
/
Child, preschool
/
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Am J Clin Nutr
Ano de publicação:
2016
Tipo de documento:
Article