MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.
Cell
; 167(3): 722-738.e23, 2016 Oct 20.
Article
em En
| MEDLINE
| ID: mdl-27768893
ABSTRACT
A functional crosstalk between epigenetic regulators and metabolic control could provide a mechanism to adapt cellular responses to environmental cues. We report that the well-known nuclear MYST family acetyl transferase MOF and a subset of its non-specific lethal complex partners reside in mitochondria. MOF regulates oxidative phosphorylation by controlling expression of respiratory genes from both nuclear and mtDNA in aerobically respiring cells. MOF binds mtDNA, and this binding is dependent on KANSL3. The mitochondrial pool of MOF, but not a catalytically deficient mutant, rescues respiratory and mtDNA transcriptional defects triggered by the absence of MOF. Mof conditional knockout has catastrophic consequences for tissues with high-energy consumption, triggering hypertrophic cardiomyopathy and cardiac failure in murine hearts; cardiomyocytes show severe mitochondrial degeneration and deregulation of mitochondrial nutrient metabolism and oxidative phosphorylation pathways. Thus, MOF is a dual-transcriptional regulator of nuclear and mitochondrial genomes connecting epigenetics and metabolism.
Palavras-chave
HAT; KANSL1; KANSL2; KANSL3; KAT; KAT8; KIAA1267; MOF; MSL1v1; MYST1; OXPHOS; acetylation; epigenetics; heart; mitochondria; mtDNA; respiration; transcription
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Transcrição Gênica
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Epigênese Genética
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Metabolismo Energético
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Histona Acetiltransferases
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Mitocôndrias Musculares
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Alemanha