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Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy.
Longo, Dario L; Stefania, Rachele; Callari, Chiara; De Rose, Francesco; Rolle, Riccardo; Conti, Laura; Consolino, Lorena; Arena, Francesca; Aime, Silvio.
Afiliação
  • Longo DL; Institute of Biostructure and Bioimaging (CNR) c/o Molecular Biotechnology Center, Via Nizza 52, 10126, Torino, Italy.
  • Stefania R; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
  • Callari C; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
  • De Rose F; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
  • Rolle R; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
  • Conti L; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
  • Consolino L; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
  • Arena F; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
  • Aime S; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
Adv Healthc Mater ; 6(1)2017 Jan.
Article em En | MEDLINE | ID: mdl-27782375
ABSTRACT
A dynamic contrast enhanced (DCE) approach for tumor photoacoustic (PA) imaging is described. Novel water soluble melanin-based derivatives are synthesized that exhibit good PA properties, stability, safety and accumulation in tumor bearing mice. This melanin derivative is capable to characterize tumor vasculature and to monitor vessel permeability changes upon antiangiogenic treatment. DCE-PA imaging can assess functional response to cancer treatments.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diagnóstico por Imagem / Técnicas Fotoacústicas / Neoplasias Mamárias Experimentais / Melaninas / Neovascularização Patológica Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Adv Healthc Mater Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diagnóstico por Imagem / Técnicas Fotoacústicas / Neoplasias Mamárias Experimentais / Melaninas / Neovascularização Patológica Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Adv Healthc Mater Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Itália