The prognostic value of MR-proadrenomedullin in patients with acute coronary syndrome complicated by cardiogenic shock.

ABSTRACT

CONTEXT Cardiogenic shock (CS) still remains one of the main causes of death in acute myocardial infarction (AMI). OBJECTIVE: The aim of this study was to evaluate the prognostic value of midregional (MR)-proadrenomedullin in AMI complicated by CS. METHODS: Forty-seven consecutive patients were included in our prospective observational study. All patients underwent coronarography and successful percutaneous coronary intervention (PCI). Plasma levels of MR-proADM were measured by a immunofluorescence method. The primary endpoint of the study, defined as cardiovascular death, occurred in 17 patients (36%). RESULTS AND CONCLUSION: Elevated plasma level of MR-proADM, determined 24 h after diagnosis of CS could be a predictor of in-hospital mortality in patients with AMI complicated by CS.