The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence.

Grabe, Grzegorz J; Zhang, Yue; Przydacz, Michal; Rolhion, Nathalie; Yang, Yi; Pruneda, Jonathan N; Komander, David; Holden, David W; Hare, Stephen A

Grabe, Grzegorz J; Zhang, Yue; Przydacz, Michal; Rolhion, Nathalie; Yang, Yi; Pruneda, Jonathan N; Komander, David; Holden, David W; Hare, Stephen A.

Afiliação

Grabe GJ; From the Section of Microbiology and.
Zhang Y; Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom and.
Przydacz M; Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom and.
Rolhion N; From the Section of Microbiology and.
Yang Y; Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom and.
Pruneda JN; the Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Cambridge CB2 OQH, United Kingdom.
Komander D; the Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Cambridge CB2 OQH, United Kingdom.
Holden DW; From the Section of Microbiology and d.holden@imperial.ac.uk.
Hare SA; Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom and s.hare@imperial.ac.uk.

J Biol Chem ; 291(50): 25853-25863, 2016 Dec 09.

Article em En | MEDLINE | ID: mdl-27789710

Assuntos

Antígenos de Bactérias/metabolismo; Proteínas de Bactérias/metabolismo; Mutação de Sentido Incorreto; Salmonella enteritidis; Salmonella typhimurium; Fatores de Virulência/metabolismo; Substituição de Aminoácidos; Animais; Antígenos de Bactérias/genética; Proteínas de Bactérias/genética; Catálise; Células HEK293; Humanos; Camundongos; Infecções por Salmonella/genética; Infecções por Salmonella/metabolismo; Salmonella enteritidis/genética; Salmonella enteritidis/metabolismo; Salmonella enteritidis/patogenicidade; Salmonella typhimurium/genética; Salmonella typhimurium/metabolismo; Salmonella typhimurium/patogenicidade; Especificidade da Espécie; Fatores de Virulência/genética

Palavras-chave

Salmonella enterica; bacterial pathogenesis; crystal structure; cysteine protease; effector; structure-function

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Salmonella enteritidis / Salmonella typhimurium / Proteínas de Bactérias / Mutação de Sentido Incorreto / Fatores de Virulência / Antígenos de Bactérias Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article

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