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Prevalence of lifetime depression in a large hemiplegic migraine cohort.
Louter, Mark A; Pelzer, Nadine; de Boer, Irene; Kuijvenhoven, Babette E C; van Oosterhout, Willebrordus P J; van Zwet, Erik W; Ferrari, Michel D; Terwindt, Gisela M.
Afiliação
  • Louter MA; From the Departments of Neurology (M.A.L., N.P., I.d.B., B.E.C.K., W.P.J.v.O., M.D.F., G.M.T.), Psychiatry (M.A.L.), and Biostatistics (E.W.v.Z.), Leiden University Medical Center, the Netherlands.
  • Pelzer N; From the Departments of Neurology (M.A.L., N.P., I.d.B., B.E.C.K., W.P.J.v.O., M.D.F., G.M.T.), Psychiatry (M.A.L.), and Biostatistics (E.W.v.Z.), Leiden University Medical Center, the Netherlands.
  • de Boer I; From the Departments of Neurology (M.A.L., N.P., I.d.B., B.E.C.K., W.P.J.v.O., M.D.F., G.M.T.), Psychiatry (M.A.L.), and Biostatistics (E.W.v.Z.), Leiden University Medical Center, the Netherlands.
  • Kuijvenhoven BE; From the Departments of Neurology (M.A.L., N.P., I.d.B., B.E.C.K., W.P.J.v.O., M.D.F., G.M.T.), Psychiatry (M.A.L.), and Biostatistics (E.W.v.Z.), Leiden University Medical Center, the Netherlands.
  • van Oosterhout WP; From the Departments of Neurology (M.A.L., N.P., I.d.B., B.E.C.K., W.P.J.v.O., M.D.F., G.M.T.), Psychiatry (M.A.L.), and Biostatistics (E.W.v.Z.), Leiden University Medical Center, the Netherlands.
  • van Zwet EW; From the Departments of Neurology (M.A.L., N.P., I.d.B., B.E.C.K., W.P.J.v.O., M.D.F., G.M.T.), Psychiatry (M.A.L.), and Biostatistics (E.W.v.Z.), Leiden University Medical Center, the Netherlands.
  • Ferrari MD; From the Departments of Neurology (M.A.L., N.P., I.d.B., B.E.C.K., W.P.J.v.O., M.D.F., G.M.T.), Psychiatry (M.A.L.), and Biostatistics (E.W.v.Z.), Leiden University Medical Center, the Netherlands.
  • Terwindt GM; From the Departments of Neurology (M.A.L., N.P., I.d.B., B.E.C.K., W.P.J.v.O., M.D.F., G.M.T.), Psychiatry (M.A.L.), and Biostatistics (E.W.v.Z.), Leiden University Medical Center, the Netherlands. g.m.terwindt@lumc.nl.
Neurology ; 87(22): 2370-2374, 2016 Nov 29.
Article em En | MEDLINE | ID: mdl-27807184
ABSTRACT

OBJECTIVE:

To determine the prevalence of depression and determinants associated with depression in a large population of hemiplegic migraine (HM) patients.

METHODS:

We conducted a cross-sectional, validated questionnaire study among 89 well-defined HM patients and 235 headache-free controls. The prevalence of lifetime depression and its relation to migraine characteristics was assessed.

RESULTS:

HM patients had increased odds for lifetime depression (odds ratio 3.73, 95% confidence interval 2.18-6.38) compared with controls. Use of acute antimigraine medication was associated with lifetime depression.

CONCLUSIONS:

Depression is part of the monogenic hemiplegic migraine phenotype. Further studies are needed to elucidate the pathophysiologic role of HM genes in comorbid depression. For now, clinicians should take comorbid depression into consideration when starting prophylactic treatment of HM.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Enxaqueca com Aura / Depressão Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Neurology Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Holanda
Buscar no Google
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Enxaqueca com Aura / Depressão Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Neurology Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Holanda