Intra-myocardial growth hormone administration ameliorates arrhythmogenesis during ischemia-reperfusion in rats.
J Electrocardiol
; 50(2): 207-210, 2017.
Article
em En
| MEDLINE
| ID: mdl-27839834
ABSTRACT
Growth hormone, currently under evaluation for the prevention of left ventricular remodeling post-myocardial infarction, displays antiarrhythmic properties in the acute setting. However, it is uncertain whether these actions are retained after ischemia/reperfusion. Using implanted telemetry transmitters, we examined the effects of prolonged, intra-myocardial growth hormone administration in conscious rats. During a 24-h observation period, ventricular tachyarrhythmias and sympathetic activation were attenuated in treated rats, whereas infarct-size was unchanged. These findings call for further study on the antiarrhythmic effects of growth hormone and on the underlying mechanisms.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio do Crescimento
/
Traumatismo por Reperfusão Miocárdica
/
Taquicardia Ventricular
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Electrocardiol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Grécia