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GS-5759, a Bifunctional ß2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells.
Joshi, Taruna; Yan, Dong; Hamed, Omar; Tannheimer, Stacey L; Phillips, Gary B; Wright, Clifford D; Kim, Musong; Salmon, Michael; Newton, Robert; Giembycz, Mark A.
Afiliação
  • Joshi T; Departments of Physiology and Pharmacology (T.J., D.Y., O.H., M.A.G.) and Cell Biology and Anatomy (R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; and Translational Medicine, Biomarkers (S.L.T.), Inflammation Research (C.D.W
  • Yan D; Departments of Physiology and Pharmacology (T.J., D.Y., O.H., M.A.G.) and Cell Biology and Anatomy (R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; and Translational Medicine, Biomarkers (S.L.T.), Inflammation Research (C.D.W
  • Hamed O; Departments of Physiology and Pharmacology (T.J., D.Y., O.H., M.A.G.) and Cell Biology and Anatomy (R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; and Translational Medicine, Biomarkers (S.L.T.), Inflammation Research (C.D.W
  • Tannheimer SL; Departments of Physiology and Pharmacology (T.J., D.Y., O.H., M.A.G.) and Cell Biology and Anatomy (R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; and Translational Medicine, Biomarkers (S.L.T.), Inflammation Research (C.D.W
  • Phillips GB; Departments of Physiology and Pharmacology (T.J., D.Y., O.H., M.A.G.) and Cell Biology and Anatomy (R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; and Translational Medicine, Biomarkers (S.L.T.), Inflammation Research (C.D.W
  • Wright CD; Departments of Physiology and Pharmacology (T.J., D.Y., O.H., M.A.G.) and Cell Biology and Anatomy (R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; and Translational Medicine, Biomarkers (S.L.T.), Inflammation Research (C.D.W
  • Kim M; Departments of Physiology and Pharmacology (T.J., D.Y., O.H., M.A.G.) and Cell Biology and Anatomy (R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; and Translational Medicine, Biomarkers (S.L.T.), Inflammation Research (C.D.W
  • Salmon M; Departments of Physiology and Pharmacology (T.J., D.Y., O.H., M.A.G.) and Cell Biology and Anatomy (R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; and Translational Medicine, Biomarkers (S.L.T.), Inflammation Research (C.D.W
  • Newton R; Departments of Physiology and Pharmacology (T.J., D.Y., O.H., M.A.G.) and Cell Biology and Anatomy (R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; and Translational Medicine, Biomarkers (S.L.T.), Inflammation Research (C.D.W
  • Giembycz MA; Departments of Physiology and Pharmacology (T.J., D.Y., O.H., M.A.G.) and Cell Biology and Anatomy (R.N.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; and Translational Medicine, Biomarkers (S.L.T.), Inflammation Research (C.D.W
J Pharmacol Exp Ther ; 360(2): 324-340, 2017 Feb.
Article em En | MEDLINE | ID: mdl-27927912
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Respiratório / Sulfonas / Regulação da Expressão Gênica / Receptores Adrenérgicos beta 2 / Quinolonas / Doença Pulmonar Obstrutiva Crônica / Células Epiteliais / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 Limite: Humans Idioma: En Revista: J Pharmacol Exp Ther Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Respiratório / Sulfonas / Regulação da Expressão Gênica / Receptores Adrenérgicos beta 2 / Quinolonas / Doença Pulmonar Obstrutiva Crônica / Células Epiteliais / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 Limite: Humans Idioma: En Revista: J Pharmacol Exp Ther Ano de publicação: 2017 Tipo de documento: Article