A biotinylated piperazine-rhodol derivative: a 'turn-on' probe for nitroreductase triggered hypoxia imaging.
Analyst
; 142(2): 345-350, 2017 01 16.
Article
em En
| MEDLINE
| ID: mdl-27966678
ABSTRACT
We developed a nitroreductase responsive theranostic probe 1; it comprises biotinylated rhodol in conjunction with p-nitrobenzyl functionality. The probe 1 showed a remarkable fluorescence 'turn-on' signal in the presence of nitroreductase under physiological conditions. The probe is considerably stable within a wide biological pH range (6-8) and also is very sensitive toward a reducing micro-environment e.g. liver microsome. Further, it enables providing cellular and in vivo nematode images in a reducing microenvironment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biotina
/
Nitrorredutases
/
Xantonas
/
Corantes Fluorescentes
/
Hipóxia
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Analyst
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China