Romidepsin induces G2/M phase arrest via Erk/cdc25C/cdc2/cyclinB pathway and apoptosis induction through JNK/c-Jun/caspase3 pathway in hepatocellular carcinoma cells.

Sun, Wei-Jian; Huang, He; He, Bin; Hu, Dan-Hong; Li, Pi-Hong; Yu, Yao-Jun; Zhou, Xiao-Hu; Lv, Zhen; Zhou, Lei; Hu, Tian-Ye; Yao, Zhi-Chao; Lu, Ming-Dong; Shen, Xian; Zheng, Zhi-Qiang

Sun, Wei-Jian; Huang, He; He, Bin; Hu, Dan-Hong; Li, Pi-Hong; Yu, Yao-Jun; Zhou, Xiao-Hu; Lv, Zhen; Zhou, Lei; Hu, Tian-Ye; Yao, Zhi-Chao; Lu, Ming-Dong; Shen, Xian; Zheng, Zhi-Qiang.

Afiliação

Sun WJ; Department of Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Huang H; Department of Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
He B; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Zhejiang University, Hangzhou, China.
Hu DH; Department of Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Li PH; Department of Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Yu YJ; Department of Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Zhou XH; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Lv Z; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhou L; Department of Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Hu TY; Department of Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Yao ZC; Department of Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Lu MD; Department of Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address: lumingdong126@126.com.
Shen X; Department of Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address: 13968888872@163.com.
Zheng ZQ; Department of Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address: zzq6529921@126.com.

Biochem Pharmacol ; 127: 90-100, 2017 03 01.

Article em En | MEDLINE | ID: mdl-28012958

Assuntos

Antineoplásicos/farmacologia; Apoptose; Carcinoma Hepatocelular/metabolismo; Depsipeptídeos/farmacologia; Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos dos fármacos; Inibidores de Histona Desacetilases/farmacologia; Neoplasias Hepáticas Experimentais/metabolismo; Animais; Antineoplásicos/uso terapêutico; Proteína Quinase CDC2; Carcinoma Hepatocelular/patologia; Caspase 3/metabolismo; Linhagem Celular Tumoral; Proliferação de Células; Ciclina B/metabolismo; Quinases Ciclina-Dependentes/metabolismo; Depsipeptídeos/uso terapêutico; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Xenoenxertos; Inibidores de Histona Desacetilases/uso terapêutico; Humanos; Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo; Neoplasias Hepáticas Experimentais/patologia; Camundongos Nus; Transplante de Neoplasias; Transdução de Sinais; Fosfatases cdc25/metabolismo

Palavras-chave

5-Fluorouracil (PubChem CID: 3385); Caspase3 pathway; Cdc2; DAPI (PubChem CID: 2954); DMSO (PubChem CID: 679); Erk; Ethanol (PubChem CID: 702); Formaldehyde solution (PubChem CID: 712); G2; Glycine (PubChem CID: 750); Hepatocellular carcinoma; JNK; M phase arrest; Methanol (PubChem CID: 887); Paraformaldehyde (PubChem CID: 123127); Romidepsin; Romidepsin (PubChem CID: 5352062); SB203580 (PubChem CID: 176155); SCH772984 (PubChem CID: 24866313); SP600125 (PubChem CID: 8515); Tween 20 (PubChem CID: 443314); Z-VAD-FMK (PubChem CID: 5497174); c-Jun; cdc25C; cyclinB pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Carcinoma Hepatocelular / Depsipeptídeos / Inibidores de Histona Desacetilases / Pontos de Checagem da Fase G2 do Ciclo Celular / Neoplasias Hepáticas Experimentais / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Biochem Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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