Spermidine boosts autophagy to protect from synapse aging.
Autophagy
; 13(2): 444-445, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-28026976
ABSTRACT
All animals form memories to adapt their behavior in a context-dependent manner. With increasing age, however, forming new memories becomes less efficient. While synaptic plasticity promotes memory formation, the etiology of age-induced memory formation remained enigmatic. Previous work showed that simple feeding of polyamine spermidine protects from age-induced memory impairment in Drosophila. Most recent work now shows that spermidine operates directly at synapses, allowing for an autophagy-dependent homeostatic regulation of presynaptic specializations. How exactly autophagic regulations intersect with synaptic plasticity should be an interesting subject for future research.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Sinapses
/
Espermidina
Limite:
Animals
Idioma:
En
Revista:
Autophagy
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Alemanha