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Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja.
Wang, Weihong; Kim, Hiyoung; Patil, Rahul S; Giri, Awadut G; Won, Dong Hwan; Hahn, Dongyup; Sung, Youjung; Lee, Jusung; Choi, Hyukjae; Nam, Sang-Jip; Kang, Heonjoong.
Afiliação
  • Wang W; Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
  • Kim H; Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
  • Patil RS; Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
  • Giri AG; Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
  • Won DH; Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
  • Hahn D; Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
  • Sung Y; Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
  • Lee J; Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
  • Choi H; College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan 38541, Republic of Korea.
  • Nam SJ; Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 03760, Republic of Korea.
  • Kang H; Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea; Research Institute of Oceanography, Seoul National University, NS-80, Seoul 08826, Republic of Korea. Electronic address: hjkang@snu.ac
Bioorg Med Chem Lett ; 27(3): 574-577, 2017 02 01.
Article em En | MEDLINE | ID: mdl-28043797
ABSTRACT
Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J-M, 1, 3-5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Urocordados / 4-Butirolactona / Farmacorresistência Bacteriana / Bactérias Gram-Positivas / Antibacterianos Limite: Animals País/Região como assunto: Asia Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Urocordados / 4-Butirolactona / Farmacorresistência Bacteriana / Bactérias Gram-Positivas / Antibacterianos Limite: Animals País/Região como assunto: Asia Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article