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MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.
Kerry, Jon; Godfrey, Laura; Repapi, Emmanouela; Tapia, Marta; Blackledge, Neil P; Ma, Helen; Ballabio, Erica; O'Byrne, Sorcha; Ponthan, Frida; Heidenreich, Olaf; Roy, Anindita; Roberts, Irene; Konopleva, Marina; Klose, Robert J; Geng, Huimin; Milne, Thomas A.
Afiliação
  • Kerry J; MRC, Molecular Haematology Unit, NIHR Oxford Biomedical Research Centre Programme, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
  • Godfrey L; MRC, Molecular Haematology Unit, NIHR Oxford Biomedical Research Centre Programme, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
  • Repapi E; Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
  • Tapia M; MRC, Molecular Haematology Unit, NIHR Oxford Biomedical Research Centre Programme, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
  • Blackledge NP; Laboratory of Chromatin Biology and Transcription, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
  • Ma H; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Ballabio E; MRC, Molecular Haematology Unit, NIHR Oxford Biomedical Research Centre Programme, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
  • O'Byrne S; Department of Paediatrics, University of Oxford, Children's Hospital, John Radcliffe, Oxford OX3 9DU, UK.
  • Ponthan F; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK.
  • Heidenreich O; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK.
  • Roy A; Department of Paediatrics, University of Oxford, Children's Hospital, John Radcliffe, Oxford OX3 9DU, UK.
  • Roberts I; MRC, Molecular Haematology Unit, NIHR Oxford Biomedical Research Centre Programme, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK; Department of Paediatrics, University of Oxford, Children's Hospital, John Radcliffe, Oxford OX3 9DU, UK.
  • Konopleva M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Klose RJ; Laboratory of Chromatin Biology and Transcription, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
  • Geng H; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Milne TA; MRC, Molecular Haematology Unit, NIHR Oxford Biomedical Research Centre Programme, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK. Electronic address: thomas.milne@imm.ox.ac.uk.
Cell Rep ; 18(2): 482-495, 2017 01 10.
Article em En | MEDLINE | ID: mdl-28076791
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia / Proteínas de Fusão Oncogênica / Elementos Facilitadores Genéticos / Proteína de Leucina Linfoide-Mieloide / Metiltransferases Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Cell Rep Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia / Proteínas de Fusão Oncogênica / Elementos Facilitadores Genéticos / Proteína de Leucina Linfoide-Mieloide / Metiltransferases Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Cell Rep Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido