Pharmacological strategies to target oncogenic KRAS signaling in pancreatic cancer.

Chuang, Hsiao-Ching; Huang, Po-Hsien; Kulp, Samuel K; Chen, Ching-Shih

Chuang, Hsiao-Ching; Huang, Po-Hsien; Kulp, Samuel K; Chen, Ching-Shih.

Afiliação

Chuang HC; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Huang PH; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Kulp SK; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Chen CS; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA; Institute of Biological Chemistry, Academia Sinica, 128 Sec. 2, Academia Road, Nangang, Taipei 115, Taiwan. Electronic address: chencs@gate.sinica.edu.tw.

Pharmacol Res ; 117: 370-376, 2017 03.

Article em En | MEDLINE | ID: mdl-28077300

Assuntos

Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Oncogenes/efeitos dos fármacos; Neoplasias Pancreáticas/tratamento farmacológico; Transdução de Sinais/efeitos dos fármacos; Proteínas ras/metabolismo; Animais; Humanos; Neoplasias Pancreáticas/metabolismo

Palavras-chave

G-duadruplex; KRAS G12C mutant-specific inhibitors; KRAS membrane anchorage; KRAS post-translational modifications; KRAS-ILK regulatory loop; KRAS-binding ligands; Oncogenic KRAS; Pancreatic cancer; Pharmacological inhibitors; RAS-binding domain inhibitors; RAS-effector interactions; YES-associated protein 1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oncogenes / Neoplasias Pancreáticas / Transdução de Sinais / Proteínas ras / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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