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Pelvic lymphadenectomy and transperineal interstitial implantation of IR 192 combined with external beam radiotherapy for bulky stage C prostatic carcinoma.
Brindle, J S; Martinez, A; Schray, M; Edmundson, G; Benson, R C; Zincke, H; Diokno, A; Gonzalez, J.
Afiliação
  • Brindle JS; Dept of Radiation Oncology, MedCenter One, Bismarck, ND 58501.
Int J Radiat Oncol Biol Phys ; 17(5): 1063-6, 1989 Nov.
Article em En | MEDLINE | ID: mdl-2808040
From January 1983 until June 1987, 51 patients with locally advanced prostatic carcinoma (47 Stage C, 4 bulky B2) were treated at Mayo Clinic (33 patients) and at William Beaumont Hospital (18 patients) with (a) 5 Gy delivered pre-operatively in one fraction, (b) pelvic lymphadenectomy and (c) interstitial implantation of the prostate with Ir 192 seeds via a perineal template (the Martinez Universal Perineal Interstitial Template) to deliver 35 Gy, and (d) 30.6 Gy external beam therapy in 17 fractions to prostate only fields. Initial clinical response has been excellent. Local control, with a median follow-up of 45 months, has been 100% by clinical exam and 84.5% pathologically in the subset biopsied. Disease-free actuarial survival at 5 years is 89%. Major toxicity has been limited to the rectum, but a modification of the brachytherapy technique has reduced this sharply. We conclude that bulky Stage C prostatic carcinoma can be successfully treated by this aggressive combination of modalities with acceptable toxicity.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pelve / Neoplasias da Próstata / Braquiterapia / Radioisótopos de Irídio / Excisão de Linfonodo Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Int J Radiat Oncol Biol Phys Ano de publicação: 1989 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pelve / Neoplasias da Próstata / Braquiterapia / Radioisótopos de Irídio / Excisão de Linfonodo Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Int J Radiat Oncol Biol Phys Ano de publicação: 1989 Tipo de documento: Article