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Discovery of a Phosphoinositide 3-Kinase (PI3K) ß/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kß Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856.
Perreault, Stephane; Chandrasekhar, Jayaraman; Cui, Zhi-Hua; Evarts, Jerry; Hao, Jia; Kaplan, Joshua A; Kashishian, Adam; Keegan, Kathleen S; Kenney, Thomas; Koditek, David; Lad, Latesh; Lepist, Eve-Irene; McGrath, Mary E; Patel, Leena; Phillips, Bart; Therrien, Joseph; Treiberg, Jennifer; Yahiaoui, Anella; Phillips, Gary.
Afiliação
  • Perreault S; Gilead Sciences, Inc. , 199 E. Blaine Street, Seattle, Washington 98102, United States.
  • Chandrasekhar J; Gilead Sciences, Inc. , 199 E. Blaine Street, Seattle, Washington 98102, United States.
  • Cui ZH; Gilead Sciences, Inc. , 199 E. Blaine Street, Seattle, Washington 98102, United States.
  • Evarts J; Gilead Sciences, Inc. , 199 E. Blaine Street, Seattle, Washington 98102, United States.
  • Hao J; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Kaplan JA; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Kashishian A; Gilead Sciences, Inc. , 199 E. Blaine Street, Seattle, Washington 98102, United States.
  • Keegan KS; Gilead Sciences, Inc. , 199 E. Blaine Street, Seattle, Washington 98102, United States.
  • Kenney T; Gilead Sciences, Inc. , 199 E. Blaine Street, Seattle, Washington 98102, United States.
  • Koditek D; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Lad L; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Lepist EI; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • McGrath ME; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Patel L; Gilead Sciences, Inc. , 199 E. Blaine Street, Seattle, Washington 98102, United States.
  • Phillips B; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Therrien J; Gilead Sciences, Inc. , 199 E. Blaine Street, Seattle, Washington 98102, United States.
  • Treiberg J; Gilead Sciences, Inc. , 199 E. Blaine Street, Seattle, Washington 98102, United States.
  • Yahiaoui A; Gilead Sciences, Inc. , 199 E. Blaine Street, Seattle, Washington 98102, United States.
  • Phillips G; Gilead Sciences, Inc. , 199 E. Blaine Street, Seattle, Washington 98102, United States.
J Med Chem ; 60(4): 1555-1567, 2017 02 23.
Article em En | MEDLINE | ID: mdl-28106991
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Inibidores de Proteínas Quinases / PTEN Fosfo-Hidrolase / Inibidores de Fosfoinositídeo-3 Quinase Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Inibidores de Proteínas Quinases / PTEN Fosfo-Hidrolase / Inibidores de Fosfoinositídeo-3 Quinase Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos