[Potential neurocognitive consequences of infection by human respiratory syncytial virus]. / Potenciales consecuencias neurocognitivas de infección por virus respiratorio sincicial humano.
Rev Chilena Infectol
; 33(5): 537-542, 2016 Oct.
Article
em Es
| MEDLINE
| ID: mdl-28112337
ABSTRACT
Human respiratory syncytial virus (RSV) infection remains as a major cause of morbidity and mortality among pediatric population. Immune response is poor and unable to establish a long term effective protection against this virus. Of particular interest has been the description of extrapulmonary manifestations of RSV infection in liver, kidney, endocrine system, heart and brain, associated to infection of peripheral blood. In the central nervous system (CNS), recent studies in animals have suggested long term neurocognitive impairment due to a direct damage from the virus. This was prevented in rats by a recombinant BCG vaccine expressing a nucleoprotein N of RSV that produces an effective immune response against the virus, not allowing its dissemination to the CNS. These findings in animal models highlight the importance of conducting more specific studies in children affected with severe infection by RSV. Therefore, our group is currently conducting an assessment of the possible long-term cognitive impairment in children under 2 years. The results of this study could be a strong argument to continue looking for an effective method for protecting against RSV infection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Vírus Respiratório Sincicial
/
Viroses do Sistema Nervoso Central
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
Es
Revista:
Rev Chilena Infectol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Chile