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Dynamic Optical Contrast Imaging.
Kim, Irene A; Taylor, Zachary D; Cheng, Harrison; Sebastian, Christine; Maccabi, Ashkan; Garritano, James; Tajudeen, Bobby; Razfar, Ali; Palma Diaz, Fernando; Yeh, Michael; Stafsudd, Oscar; Grundfest, Warren; St John, Maie.
Afiliação
  • Kim IA; 1 Department of Head and Neck Surgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Taylor ZD; 2 Head and Neck Cancer Program, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Cheng H; 2 Head and Neck Cancer Program, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Sebastian C; 3 Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, California, USA.
  • Maccabi A; 4 Department of Surgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Garritano J; 3 Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, California, USA.
  • Tajudeen B; 1 Department of Head and Neck Surgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Razfar A; 2 Head and Neck Cancer Program, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Palma Diaz F; 3 Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, California, USA.
  • Yeh M; 3 Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, California, USA.
  • Stafsudd O; 1 Department of Head and Neck Surgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • Grundfest W; 2 Head and Neck Cancer Program, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
  • St John M; 1 Department of Head and Neck Surgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
Otolaryngol Head Neck Surg ; 156(3): 480-483, 2017 03.
Article em En | MEDLINE | ID: mdl-28116982
The variable location and indistinct features of parathyroid glands can make their intraoperative identification challenging. Currently, there exists no routine use of localization methods during surgery. Dynamic optical contrast imaging (DOCI) leverages a novel realization of temporally dependent measurements of tissue autofluorescence that allows the acquisition of specific tissue properties. A prospective series of patients with primary hyperparathyroidism was examined. Parathyroid lesions and surrounding tissues were collected; fluorescence decay images were acquired via DOCI. Ex vivo samples (81 patients) were processed for histologic assessment. DOCI extracts relative fluorescence decay information in a surgically relevant field of view with a clinically accessible acquisition time <2 minutes. Analysis of DOCI revealed microscopic characterization sufficient for tissue type identification consistent with histology ( P < .05). DOCI is capable of efficiently distinguishing parathyroid tissue from adjacent tissues. Such an intraoperative tool would be transformative, helping surgeons to identify lesions, preserve healthy tissue, and improve patient outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glândulas Paratireoides / Imagem Óptica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Otolaryngol Head Neck Surg Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glândulas Paratireoides / Imagem Óptica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Otolaryngol Head Neck Surg Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos