[Dialogues between cell nuclei and mitochondria]. / Dialogi pomiedzy jadrem a mitochondriami.
Postepy Biochem
; 62(2): 158-161, 2016.
Article
em Pl
| MEDLINE
| ID: mdl-28132467
ABSTRACT
Mitochondria are not only ATP producing organelles, but they play pivotal roles in apoptosis, neurodegeneration, cancer and aging. Mammalian mitochondrial genome is a small DNA molecule of about 16.5 kb, encoding less than 20 polypeptides and a set of ribosomal RNAs and tRNAs. In order to ensure proper cell functioning a continous communication between cell nucleus and mitochondria must be maintained. This review presents novel developments in the field of nucleo-mitochondrial communications. We discuss the import of regulatory cytosolic miRNAs into mitochondria, export of RNA from mitochondria, the existence of novel 3 polypeptides encoded by the mitochondrial genome and the transfer of mitochondrial DNA to nuclear genomes. Mechanisms of these processes and their significance for cellular homeostasis are poorly known and present an important challenge for molecular biology.
Palavras-chave
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Núcleo Celular
/
Regulação da Expressão Gênica
/
Mitocôndrias
Limite:
Animals
/
Humans
Idioma:
Pl
Revista:
Postepy Biochem
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Polônia