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BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants.
Timmers, Maarten; Barão, Soraia; Van Broeck, Bianca; Tesseur, Ina; Slemmon, John; De Waepenaert, Katja; Bogert, Jennifer; Shaw, Leslie M; Engelborghs, Sebastiaan; Moechars, Dieder; Mercken, Marc; Van Nueten, Luc; Tritsmans, Luc; de Strooper, Bart; Streffer, Johannes Rolf.
Afiliação
  • Timmers M; Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.
  • Barão S; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
  • Van Broeck B; VIB Center for the Biology of Disease, VIB-Leuven, Belgium.
  • Tesseur I; Center for Human Genetics, Universitaire ziekenhuizen and LIND, KU Leuven, Belgium.
  • Slemmon J; Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.
  • De Waepenaert K; Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.
  • Bogert J; Janssen Research and Development LLC, La Jolla, CA, USA.
  • Shaw LM; Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.
  • Engelborghs S; Janssen Research and Development LLC, Raritan, NJ, USA.
  • Moechars D; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Mercken M; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
  • Van Nueten L; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium.
  • Tritsmans L; Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.
  • de Strooper B; Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.
  • Streffer JR; Janssen Research and Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium.
J Alzheimers Dis ; 56(4): 1437-1449, 2017.
Article em En | MEDLINE | ID: mdl-28157093
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Peptídeos beta-Amiloides / Ácido Aspártico Endopeptidases / Proteínas tau / Secretases da Proteína Precursora do Amiloide Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Bélgica
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Peptídeos beta-Amiloides / Ácido Aspártico Endopeptidases / Proteínas tau / Secretases da Proteína Precursora do Amiloide Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Bélgica