Phenotypic screening of cannabinoid receptor 2 ligands shows different sensitivity to genotype.

Hillger, Julia M; le Roy, Beau; Wang, Zi; Mulder-Krieger, Thea; Boomsma, Dorret I; Slagboom, P Eline; Danen, Erik H J; IJzerman, Adriaan P; Heitman, Laura H

Hillger, Julia M; le Roy, Beau; Wang, Zi; Mulder-Krieger, Thea; Boomsma, Dorret I; Slagboom, P Eline; Danen, Erik H J; IJzerman, Adriaan P; Heitman, Laura H.

Afiliação

Hillger JM; Division of Medicinal Chemistry, LACDR, Leiden University, The Netherlands.
le Roy B; Division of Medicinal Chemistry, LACDR, Leiden University, The Netherlands.
Wang Z; Division of Toxicology, LACDR, Leiden University, The Netherlands.
Mulder-Krieger T; Division of Medicinal Chemistry, LACDR, Leiden University, The Netherlands.
Boomsma DI; Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands.
Slagboom PE; Section of Molecular Epidemiology, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, The Netherlands.
Danen EHJ; Division of Toxicology, LACDR, Leiden University, The Netherlands.
IJzerman AP; Division of Medicinal Chemistry, LACDR, Leiden University, The Netherlands.
Heitman LH; Division of Medicinal Chemistry, LACDR, Leiden University, The Netherlands. Electronic address: l.h.heitman@lacdr.leidenuniv.nl.

Biochem Pharmacol ; 130: 60-70, 2017 04 15.

Article em En | MEDLINE | ID: mdl-28159624

Assuntos

Canabinoides/metabolismo; Receptor CB2 de Canabinoide/metabolismo; Células Cultivadas; Genótipo; Humanos; Ligantes; Fenótipo

Palavras-chave

2-AG (PubMed CID: 5282280); AEA (PubMed CID: 5281969); AM251 (PubMed CID: 2125); AM630 (PubMed CID: 4302963); BAY59-3074 (PubMed CID: 10479060); CP55940 (PubMed CID: 10479060); Cannabinoid receptor 2; GW405833 (PubMed CID: 46916568); JWH133 (PubMed CID: 6918505); Label-free; Lymphoblastoid cell lines; Precision medicine; Single Nucleotide Polymorphism; WIN55212-2 (PubMed CID: 5311501)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canabinoides / Receptor CB2 de Canabinoide Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Biochem Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Holanda

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