Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis.

Chuang, Chen-Hua; Greenside, Peyton G; Rogers, Zoë N; Brady, Jennifer J; Yang, Dian; Ma, Rosanna K; Caswell, Deborah R; Chiou, Shin-Heng; Winters, Aidan F; Grüner, Barbara M; Ramaswami, Gokul; Spencley, Andrew L; Kopecky, Kimberly E; Sayles, Leanne C; Sweet-Cordero, E Alejandro; Li, Jin Billy; Kundaje, Anshul; Winslow, Monte M

Chuang, Chen-Hua; Greenside, Peyton G; Rogers, Zoë N; Brady, Jennifer J; Yang, Dian; Ma, Rosanna K; Caswell, Deborah R; Chiou, Shin-Heng; Winters, Aidan F; Grüner, Barbara M; Ramaswami, Gokul; Spencley, Andrew L; Kopecky, Kimberly E; Sayles, Leanne C; Sweet-Cordero, E Alejandro; Li, Jin Billy; Kundaje, Anshul; Winslow, Monte M.

Afiliação

Chuang CH; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.
Greenside PG; Biomedical Informatics Training Program, Stanford University School of Medicine, Stanford, California, USA.
Rogers ZN; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.
Brady JJ; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.
Yang D; Cancer Biology Program, Stanford University School of Medicine, Stanford, California, USA.
Ma RK; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.
Caswell DR; Cancer Biology Program, Stanford University School of Medicine, Stanford, California, USA.
Chiou SH; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.
Winters AF; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.
Grüner BM; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.
Ramaswami G; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.
Spencley AL; Cancer Biology Program, Stanford University School of Medicine, Stanford, California, USA.
Kopecky KE; Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
Sayles LC; Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Sweet-Cordero EA; Cancer Biology Program, Stanford University School of Medicine, Stanford, California, USA.
Li JB; Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Kundaje A; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.
Winslow MM; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.

Nat Med ; 23(3): 291-300, 2017 Mar.

Article em En | MEDLINE | ID: mdl-28191885

Assuntos

Adenocarcinoma/genética; Antígenos CD/genética; Regulação Neoplásica da Expressão Gênica/genética; Janus Quinases/genética; Neoplasias Pulmonares/genética; Proteínas de Neoplasias/genética; Fator de Transcrição STAT3/genética; Adenocarcinoma/metabolismo; Animais; Western Blotting; Linhagem Celular Tumoral; Modelos Animais de Doenças; Técnicas de Silenciamento de Genes; Janus Quinase 1/genética; Janus Quinase 3/genética; Neoplasias Pulmonares/metabolismo; Camundongos; Terapia de Alvo Molecular; Metástase Neoplásica/genética; Reação em Cadeia da Polimerase; Inibidores de Proteínas Quinases; Proteínas Proto-Oncogênicas p21(ras)/genética; Transdução de Sinais; Proteína Supressora de Tumor p53/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenocarcinoma / Antígenos CD / Regulação Neoplásica da Expressão Gênica / Fator de Transcrição STAT3 / Janus Quinases / Neoplasias Pulmonares / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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