A single-stranded DNA aptamer against mannose-capped lipoarabinomannan enhances anti-tuberculosis activity of macrophages through downregulation of lipid-sensing nuclear receptor peroxisome proliferator-activated receptor Î³ expression.

Pan, Qin; Yan, Jiamin; Liu, Qi; Yuan, Chunhui; Zhang, Xiao-Lian

Pan, Qin; Yan, Jiamin; Liu, Qi; Yuan, Chunhui; Zhang, Xiao-Lian.

Afiliação

Pan Q; State Key Laboratory of Virology and Medical Research Institue, Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, P. R. China.
Yan J; State Key Laboratory of Virology and Medical Research Institue, Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, P. R. China.
Liu Q; State Key Laboratory of Virology and Medical Research Institue, Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, P. R. China.
Yuan C; State Key Laboratory of Virology and Medical Research Institue, Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, P. R. China.
Zhang XL; State Key Laboratory of Virology and Medical Research Institue, Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, P. R. China.

Microbiol Immunol ; 61(2): 92-102, 2017 Feb.

Article em En | MEDLINE | ID: mdl-28206680

Assuntos

Aptâmeros de Nucleotídeos/metabolismo; Regulação para Baixo; Fatores Imunológicos/metabolismo; Lipopolissacarídeos/metabolismo; Macrófagos Peritoneais/imunologia; Mycobacterium tuberculosis/imunologia; PPAR gama/biossíntese; Animais; Células Cultivadas; DNA de Cadeia Simples/metabolismo; Endocitose/efeitos dos fármacos; Macrófagos Peritoneais/efeitos dos fármacos; Camundongos Endogâmicos BALB C; Receptores Citoplasmáticos e Nucleares/biossíntese

Palavras-chave

aptamer; inducible nitric oxide synthase; mannose-capped lipoarabinomannan

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação para Baixo / Lipopolissacarídeos / Macrófagos Peritoneais / PPAR gama / Aptâmeros de Nucleotídeos / Fatores Imunológicos / Mycobacterium tuberculosis Limite: Animals Idioma: En Revista: Microbiol Immunol Ano de publicação: 2017 Tipo de documento: Article

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