New options in the management of intractable ALK(+) metastatic non-small-cell lung cancer.
Lung Cancer (Auckl)
; 5: 35-42, 2014.
Article
em En
| MEDLINE
| ID: mdl-28210140
ABSTRACT
Non-small-cell lung cancer (NSCLC) is a heterogeneous disease and a challenging malignancy to treat, as many patients have advanced disease at the time of diagnosis. Recent advances have led to the identification of molecularly defined subtypes of NSCLC, namely for patients with adenocarcinoma histology. The most recently identified molecular target is the anaplastic lymphoma kinase (ALK) gene rearrangement, and patient responses to the ALK inhibitor crizotinib have led to its approval in this selected patient population. Like other tyrosine kinase inhibitors, resistance to crizotinib ultimately develops by various mechanisms requiring alternative therapeutic options. This review article discusses the management of patients with the ALK gene rearrangement, mechanisms of crizotinib resistance, and future potential therapeutic options.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Lung Cancer (Auckl)
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos