Production of IL-1 alpha and IL-1 beta by clones of EBV transformed, human B cells.
Mol Immunol
; 24(5): 479-85, 1987 May.
Article
em En
| MEDLINE
| ID: mdl-2821386
ABSTRACT
An EBV transformed B-cell line was derived from peripheral blood cells from a single donor. B-cell clones were isolated from that line and analyzed for transcription of IL-1 genes, production of biologically detectable IL-1 and antigen presenting capabilities. One clone was found to secrete IL-1 activity into tissue culture medium, and to express the gene for IL-1 alpha. Three other clones were positive for cell surface IL-1 activity but no activity could be detected in culture supernatants. Those clones express the gene for IL-1 beta but not IL-1 alpha. All clones were approximately equal in their ability to present antigen to resting and primed T cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Transformação Celular Viral
/
Interleucina-1
/
Herpesvirus Humano 4
Limite:
Humans
Idioma:
En
Revista:
Mol Immunol
Ano de publicação:
1987
Tipo de documento:
Article