Patients With Long-QT Syndrome Caused by Impaired <i>hERG</i>-Encoded K<sub>v</sub>11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia.

Hyltén-Cavallius, Louise; Iepsen, Eva W; Wewer Albrechtsen, Nicolai J; Svendstrup, Mathilde; Lubberding, Anniek F; Hartmann, Bolette; Jespersen, Thomas; Linneberg, Allan; Christiansen, Michael; Vestergaard, Henrik; Pedersen, Oluf; Holst, Jens J; Kanters, Jørgen K; Hansen, Torben; Torekov, Signe S

Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded K_v11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia.

Hyltén-Cavallius, Louise; Iepsen, Eva W; Wewer Albrechtsen, Nicolai J; Svendstrup, Mathilde; Lubberding, Anniek F; Hartmann, Bolette; Jespersen, Thomas; Linneberg, Allan; Christiansen, Michael; Vestergaard, Henrik; Pedersen, Oluf; Holst, Jens J; Kanters, Jørgen K; Hansen, Torben; Torekov, Signe S.

Afiliação

Hyltén-Cavallius L; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer
Iepsen EW; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer
Wewer Albrechtsen NJ; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer
Svendstrup M; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer
Lubberding AF; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer
Hartmann B; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer
Jespersen T; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer
Linneberg A; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer
Christiansen M; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer
Vestergaard H; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer
Pedersen O; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer
Holst JJ; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer
Kanters JK; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer
Hansen T; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer
Torekov SS; From Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.H.-C., E.W.I., N.J.W.A., A.F.L., B.H., T.J., M.C., J.J.H., J.K.K., S.S.T.); Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, Univer

Circulation ; 135(18): 1705-1719, 2017 May 02.

Article em En | MEDLINE | ID: mdl-28235848

Assuntos

Glicemia/metabolismo; Canal de Potássio ERG1/genética; Sistema de Condução Cardíaco/fisiopatologia; Hipoglicemia/etiologia; Incretinas/metabolismo; Ilhotas Pancreáticas/metabolismo; Síndrome do QT Longo/genética; Mutação; Potenciais de Ação; Adulto; Animais; Biomarcadores/sangue; Glicemia/efeitos dos fármacos; Peptídeo C/sangue; Estudos de Casos e Controles; Linhagem Celular Tumoral; Canal de Potássio ERG1/antagonistas & inibidores; Canal de Potássio ERG1/metabolismo; Eletrocardiografia; Feminino; Polipeptídeo Inibidor Gástrico/sangue; Predisposição Genética para Doença; Glucagon/sangue; Peptídeo 1 Semelhante ao Glucagon/sangue; Teste de Tolerância a Glucose; Sistema de Condução Cardíaco/metabolismo; Humanos; Hipoglicemia/sangue; Hipoglicemia/diagnóstico; Hipoglicemia/fisiopatologia; Insulina/sangue; Síndrome do QT Longo/sangue; Síndrome do QT Longo/diagnóstico; Síndrome do QT Longo/fisiopatologia; Masculino; Camundongos; Pessoa de Meia-Idade; Fenótipo; Bloqueadores dos Canais de Potássio/farmacologia; Interferência de RNA; Ratos Wistar; Fatores de Tempo; Transfecção

Palavras-chave

arrhythmias, cardiac; glucagon; glucagon-like peptide 1 (GLP-1); glucose; hyperglycemia; hypoglycemia; insulin-secreting cells; long-QT syndrome; potassium channels, voltage-gated

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Síndrome do QT Longo / Ilhotas Pancreáticas / Incretinas / Canal de Potássio ERG1 / Sistema de Condução Cardíaco / Hipoglicemia / Mutação Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Circulation Ano de publicação: 2017 Tipo de documento: Article

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