PPAR&#945;/Î³ antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats.

Zhao, Xi; Wang, Feng; Zhou, Ruijun; Zhu, Zengyan; Xie, Meilin

PPARα/Î³ antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats.

Zhao, Xi; Wang, Feng; Zhou, Ruijun; Zhu, Zengyan; Xie, Meilin.

Afiliação

Zhao X; Department of Pharmacology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu Province, China.
Wang F; Department of Pharmaceutical Laboratory, School of Pharmacy, Nantong University, Nantong, 226001, Jiangsu Province, China.
Zhou R; Department of Pharmacology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu Province, China.
Zhu Z; Department of Pharmacology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu Province, China.
Xie M; Department of Pharmacology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu Province, China.

Inflammopharmacology ; 26(2): 425-433, 2018 Apr.

Article em En | MEDLINE | ID: mdl-28236037

Assuntos

Cumarínicos/farmacologia; Inflamação/tratamento farmacológico; Metabolismo dos Lipídeos/efeitos dos fármacos; Fígado/efeitos dos fármacos; PPAR alfa/antagonistas & inibidores; PPAR gama/antagonistas & inibidores; Anilidas/farmacologia; Animais; Ácidos Graxos não Esterificados/metabolismo; Fígado Gorduroso; Indóis/farmacologia; Inflamação/metabolismo; Masculino; Ratos; Ratos Sprague-Dawley; Triglicerídeos/metabolismo

Palavras-chave

Inflammatory response; Lipid metabolism; Nonalcoholic steatohepatitis; Osthole; Peroxisome proliferator-activated receptor α/Î³

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cumarínicos / PPAR alfa / PPAR gama / Metabolismo dos Lipídeos / Inflamação / Fígado Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Inflammopharmacology Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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