Effects of 4'-O-tetrahydropyranyl-doxorubicin on isolated perfused rat heart and cardiac mitochondrial cytochrome C oxidase activity.
Anticancer Res
; 7(4B): 803-6, 1987.
Article
em En
| MEDLINE
| ID: mdl-2823684
ABSTRACT
The acute cardiac effects of the antitumour anthracycline 4'-O-tetrahydropyranyl-doxorubicin (THP) were studied on isolated, perfused, spontaneously beating rat hearts and on cardiac mitochondrial cytochrome c oxidase activity. Perfusion for 1 hour with 2.5 or 5.0 micrograms/ml of THP was associated with a marked widening of the QRS complex and the S alpha T segment, as well as with a reduction of the R- and T-wave amplitude, the heart rate, the isometric systolic tension and the coronary flow. Heart perfusion with equimolar doses of doxorubicin (2.2 or 4.4 micrograms/ml) induced a significant enlargement of the SaT segment and a reduction in the heart rate and the coronary flow. Both anthracyclines inhibited the cytochrome c oxidase activity in a dose-dependent manner; however, THP exerted a significant inhibition at concentrations higher than doxorubicin (20 microM). Results demonstrate that THP induces a higher degree of acute cardiotoxicity on isolated rat hearts compared with doxorubicin. The reduced inhibitory effect of THP on the cytochrome c oxidase activity of isolated heart mitochondria is consistent with the lower degree of chronic cardiotoxicity displayed by THP in animals and humans.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doxorrubicina
/
Complexo IV da Cadeia de Transporte de Elétrons
/
Coração
/
Mitocôndrias Cardíacas
Limite:
Animals
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
Itália