Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.

Nelson, Marin E; Lahiri, Sujoy; Chow, Jenny D Y; Byrne, Frances L; Hargett, Stefan R; Breen, David S; Olzomer, Ellen M; Wu, Lindsay E; Cooney, Gregory J; Turner, Nigel; James, David E; Slack-Davis, Jill K; Lackner, Carolin; Caldwell, Stephen H; Hoehn, Kyle L

Nelson, Marin E; Lahiri, Sujoy; Chow, Jenny D Y; Byrne, Frances L; Hargett, Stefan R; Breen, David S; Olzomer, Ellen M; Wu, Lindsay E; Cooney, Gregory J; Turner, Nigel; James, David E; Slack-Davis, Jill K; Lackner, Carolin; Caldwell, Stephen H; Hoehn, Kyle L.

Afiliação

Nelson ME; Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA.
Lahiri S; Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA.
Chow JD; Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA.
Byrne FL; Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA.
Hargett SR; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.
Breen DS; Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA.
Olzomer EM; Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA.
Wu LE; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.
Cooney GJ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.
Turner N; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales 2006, Australia.
James DE; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia.
Slack-Davis JK; School of Medicine, The University of Sydney, Sydney, New South Wales 2006, Australia.
Lackner C; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.
Caldwell SH; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales 2006, Australia.
Hoehn KL; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia.

Nat Commun ; 8: 14689, 2017 03 14.

Article em En | MEDLINE | ID: mdl-28290443

Assuntos

Acetil-CoA Carboxilase/genética; Carcinogênese/metabolismo; Carcinoma Hepatocelular/metabolismo; Sobrevivência Celular/genética; Lipogênese/genética; Neoplasias Hepáticas Experimentais/metabolismo; Neoplasias Hepáticas/metabolismo; Fígado/metabolismo; Acetil-CoA Carboxilase/metabolismo; Alquilantes/toxicidade; Animais; Antioxidantes; Carcinogênese/efeitos dos fármacos; Carcinoma Hepatocelular/induzido quimicamente; Carcinoma Hepatocelular/genética; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Dietilnitrosamina/toxicidade; Glutationa/metabolismo; Células Hep G2; Humanos; Metabolismo dos Lipídeos/efeitos dos fármacos; Metabolismo dos Lipídeos/genética; Fígado/efeitos dos fármacos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas Experimentais/induzido quimicamente; Neoplasias Hepáticas Experimentais/genética; Metabolômica; Camundongos; Camundongos Knockout; NADP/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetil-CoA Carboxilase / Sobrevivência Celular / Carcinoma Hepatocelular / Lipogênese / Carcinogênese / Fígado / Neoplasias Hepáticas / Neoplasias Hepáticas Experimentais Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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