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Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1.
Li, Ao; Yadav, Rahul; White, Jessica K; Herroon, Mackenzie K; Callahan, Brian P; Podgorski, Izabela; Turro, Claudia; Scott, Emily E; Kodanko, Jeremy J.
Afiliação
  • Li A; Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. jkodanko@chem.wayne.edu.
  • Yadav R; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • White JK; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
  • Herroon MK; Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA.
  • Callahan BP; Department of Chemistry, Binghamton University, Binghamton, New York 13902, USA.
  • Podgorski I; Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA and Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA.
  • Turro C; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
  • Scott EE; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Kodanko JJ; Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. jkodanko@chem.wayne.edu and Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA.
Chem Commun (Camb) ; 53(26): 3673-3676, 2017 Mar 28.
Article em En | MEDLINE | ID: mdl-28304025
ABSTRACT
New Ru(ii)-caged abiraterone complexes were synthesized that exhibit strong absorption in the visible region and release the steroidal CYP17A1 inhibitor abiraterone upon exposure to low energy visible light in buffer and prostate cancer cells. Photoinduced release results in abiraterone binding to its CYP17A1 target in an inhibitory mode.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Rutênio / Esteroide 17-alfa-Hidroxilase / Complexos de Coordenação / Inibidores das Enzimas do Citocromo P-450 / Antineoplásicos Limite: Humans / Male Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Rutênio / Esteroide 17-alfa-Hidroxilase / Complexos de Coordenação / Inibidores das Enzimas do Citocromo P-450 / Antineoplásicos Limite: Humans / Male Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos