A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues.
Beilstein J Org Chem
; 13: 303-312, 2017.
Article
em En
| MEDLINE
| ID: mdl-28326139
ABSTRACT
For the synthesis of m-sulfamoylbenzamide analogues, small molecules which are known for their bioactivity, a chemoselective procedure has been developed starting from m-(chlorosulfonyl)benzoyl chloride. Although a chemoselective process in batch was already reported, a continuous-flow process reveals an increased selectivity at higher temperatures and without catalysts. In total, 15 analogues were synthesized, using similar conditions, with yields ranging between 65 and 99%. This is the first automated and chemoselective synthesis of m-sulfamoylbenzamide analogues.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Beilstein J Org Chem
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Bélgica