An Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wall.
ACS Infect Dis
; 3(7): 462-466, 2017 07 14.
Article
em En
| MEDLINE
| ID: mdl-28350438
ABSTRACT
The lipopeptide antibiotic daptomycin is active against Gram-positive pathogens. It permeabilizes bacterial cell membranes, which involves the formation of membrane-associated oligomers. We here studied a dimer of daptomycin whose two subunits were linked through a bivalent aliphatic acyl chain. Unexpectedly, the dimer had very low activity on vegetative Staphylococcus aureus and Bacillus subtilis cells. However, activity resembled that of monomeric daptomycin on liposomes and on B. subtilis L-forms. These findings underscore the importance of the bacterial cell wall in daptomycin resistance.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
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Bacillus subtilis
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Parede Celular
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Daptomicina
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Farmacorresistência Bacteriana
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Antibacterianos
Idioma:
En
Revista:
ACS Infect Dis
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Canadá