Antimicrobial sesquiterpene lactones from Artemisia sieberi.

Mohamed, Tarik A; Hegazy, Mohamed-Elamir F; Abd El Aty, Abeer A; Ghabbour, Hazem A; Alsaid, Mansour S; Shahat, Abdelaaty A; Paré, Paul W

Mohamed, Tarik A; Hegazy, Mohamed-Elamir F; Abd El Aty, Abeer A; Ghabbour, Hazem A; Alsaid, Mansour S; Shahat, Abdelaaty A; Paré, Paul W.

Afiliação

Mohamed TA; a Phytochemistry Department , National Research Centre , Giza 12622 , Egypt.
Hegazy MF; a Phytochemistry Department , National Research Centre , Giza 12622 , Egypt.
Abd El Aty AA; b Chemistry of Natural and Microbial Products Department , National Research Centre , Giza 12622 , Egypt.
Ghabbour HA; c Department of Pharmaceutical Chemistry , College of Pharmacy, King Saud University , Riyadh 11451 , Saudi Arabia.
Alsaid MS; d Faculty of Pharmacy, Department of Medicinal Chemistry , University of Mansoura , Mansoura 35516 , Egypt.
Shahat AA; e Pharmacognosy Department , College of Pharmacy, King Saud University , Riyadh 11451 , Saudi Arabia.
Paré PW; a Phytochemistry Department , National Research Centre , Giza 12622 , Egypt.

J Asian Nat Prod Res ; 19(11): 1093-1101, 2017 Nov.

Article em En | MEDLINE | ID: mdl-28361549

ABSTRACT

ABSTRACT

Two new sesquiterpene lactones 3R, 8R-dihydroxygermacr-4(15),9(10)-dien-6S,7S,11RH,12,6-olide (1) and 1R, 8S-dihydroxy-11R,13-dihydrobalchanin(2), together with two known compounds 11-epiartapshin (3) and 3'-hydroxygenkwanin (4), were isolated from Artemisia sieberi. Their structures were elucidated by 1D, 2D NMR, MS, and X-ray diffraction. Compound 4 inhibited Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus with Minimal inhibitory concentration values of 50 and 25 µg/disk, respectively. All the isolated compounds exhibited moderate antifungal activities.

Assuntos

Antibacterianos/isolamento & purificação; Antibacterianos/farmacologia; Artemisia/química; Asteraceae/química; Lactonas/isolamento & purificação; Lactonas/farmacologia; Sesquiterpenos/isolamento & purificação; Sesquiterpenos/farmacologia; Antibacterianos/química; Bacillus subtilis/efeitos dos fármacos; Lactonas/química; Testes de Sensibilidade Microbiana; Estrutura Molecular; Extratos Vegetais/química; Sesquiterpenos/química; Staphylococcus aureus/efeitos dos fármacos; Estereoisomerismo

Palavras-chave

Artemisia sieberi; Asteraceae; Sesquiterpenes; X-rays analysis; antimicrobial activity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Artemisia / Asteraceae / Lactonas / Antibacterianos Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Egito

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