Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network.

Martins, Andrew J; Narayanan, Manikandan; Prüstel, Thorsten; Fixsen, Bethany; Park, Kyemyung; Gottschalk, Rachel A; Lu, Yong; Andrews-Pfannkoch, Cynthia; Lau, William W; Wendelsdorf, Katherine V; Tsang, John S

Martins, Andrew J; Narayanan, Manikandan; Prüstel, Thorsten; Fixsen, Bethany; Park, Kyemyung; Gottschalk, Rachel A; Lu, Yong; Andrews-Pfannkoch, Cynthia; Lau, William W; Wendelsdorf, Katherine V; Tsang, John S.

Afiliação

Martins AJ; Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institutes of Health, Bethesda, MD 20892, USA.
Narayanan M; Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institutes of Health, Bethesda, MD 20892, USA.
Prüstel T; Computational Biology Section, Laboratory of Systems Biology, National Institutes of Health, Bethesda, MD 20892, USA.
Fixsen B; Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institutes of Health, Bethesda, MD 20892, USA.
Park K; Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institutes of Health, Bethesda, MD 20892, USA; Biophysics Program, University of Maryland-NIH Graduate Partnership Program, University of Maryland, College Park, MD 20742, USA.
Gottschalk RA; Lymphocyte Biology Section, Laboratory of Systems Biology, National Institutes of Health, Bethesda, MD 20892, USA.
Lu Y; Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institutes of Health, Bethesda, MD 20892, USA.
Andrews-Pfannkoch C; Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institutes of Health, Bethesda, MD 20892, USA.
Lau WW; Office of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA.
Wendelsdorf KV; Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institutes of Health, Bethesda, MD 20892, USA.
Tsang JS; Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institutes of Health, Bethesda, MD 20892, USA; Trans-NIH Center for Human Immunology (CHI), National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: john.tsang@nih.gov.

Cell Syst ; 4(4): 379-392.e12, 2017 04 26.

Article em En | MEDLINE | ID: mdl-28365150

Assuntos

Redes Reguladoras de Genes; Variação Genética; Macrófagos/fisiologia; Simulação por Computador; Expressão Gênica; Regulação da Expressão Gênica; Humanos; Interleucina-10/genética; Interleucina-10/metabolismo; Interleucina-10/fisiologia; Processos Estocásticos

Palavras-chave

IL-10; environmental perturbations; gene-gene correlations across single cells; macrophage activation; network rewiring and differential gene network analysis; noise propagation; propagation of cell-to-cell variation; single-cell genomics; stochastic modeling; transcription factor activity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Redes Reguladoras de Genes / Macrófagos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Syst Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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