Two classes of PDGF receptor recognize different isoforms of PDGF.
Science
; 240(4858): 1529-31, 1988 Jun 10.
Article
em En
| MEDLINE
| ID: mdl-2836952
ABSTRACT
Previous studies involving platelet-derived growth factor (PDGF) have been based on the premise that a single cell-surface receptor binds all three isoforms of PDGF (AA, BB, and AB). It is now shown that two populations of PDGF receptor exist and can be distinguished by their ligand binding specificity. The B receptor binds only the BB dimer, whereas the A/B receptor binds AA, BB, and AB dimers. Human dermal fibroblasts appear to express seven times as much B receptor as A/B receptor. The B receptor is responsible for most PDGF receptor phosphorylation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Fator de Crescimento Derivado de Plaquetas
/
Receptores de Superfície Celular
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1988
Tipo de documento:
Article